Gene information
Official symbol FAS
Official full name Fas cell surface death receptor
Gene type protein-coding gene
Chromosome10q23.31
Alias symbolCD95; APO-1
Previous symbolFAS1; APT1; TNFRSF6
Gene familyCD molecules; Tumor necrosis factor receptor superfamily; Death inducing signaling complex
Resources
Entrez Gene 355
HGNC HGNC:11920
Ensembl ENSG00000026103
Vega OTTHUMG00000018701
UCSC uc001kfr.4
GO terms: 46 records
GO Description Category LogP Number of genes Detail
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002260 lymphocyte homeostasis GO Biological Processes -3.29518609 9 More
GO:0009267 cellular response to starvation GO Biological Processes -4.23113258 19 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009897 external side of plasma membrane GO Cellular Components -28.0033937 46 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010950 positive regulation of endopeptidase activity GO Biological Processes -13.2452311 34 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031668 cellular response to extracellular stimulus GO Biological Processes -10.2327580 36 More
GO:0031669 cellular response to nutrient levels GO Biological Processes -9.42886914 32 More
GO:0032872 regulation of stress-activated MAPK cascade GO Biological Processes -11.6818048 20 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0042594 response to starvation GO Biological Processes -5.43370462 24 More
GO:0043029 T cell homeostasis GO Biological Processes -2.57451150 6 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0062197 cellular response to chemical stress GO Biological Processes -14.0979689 44 More
GO:0070227 lymphocyte apoptotic process GO Biological Processes -2.79007403 3 More
GO:0070302 regulation of stress-activated protein kinase signaling cascade GO Biological Processes -11.5600448 20 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071260 cellular response to mechanical stimulus GO Biological Processes -11.7214175 13 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071453 cellular response to oxygen levels GO Biological Processes -14.8173809 34 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0071887 leukocyte apoptotic process GO Biological Processes -3.56106200 4 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0098552 side of membrane GO Cellular Components -22.4625650 48 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001235 positive regulation of apoptotic signaling pathway GO Biological Processes -13.4065813 30 More
KEGG pathways: 15 records
KEGG Description Category LogP Number of genes Detail
hsa01524 Platinum drug resistance KEGG Pathway -2.75238159 5 More
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04932 Non-alcoholic fatty liver disease KEGG Pathway -11.2628136 17 More
hsa05010 Alzheimer disease KEGG Pathway -5.39034067 17 More
hsa05022 Pathways of neurodegeneration - multiple diseases KEGG Pathway -4.18311884 18 More
hsa05143 African trypanosomiasis KEGG Pathway -18.5080428 15 More
hsa05160 Hepatitis C KEGG Pathway -4.71256920 10 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05167 Kaposi sarcoma-associated herpesvirus infection KEGG Pathway -9.05308086 17 More
hsa05168 Herpes simplex virus 1 infection KEGG Pathway -3.99478875 17 More
hsa05169 Epstein-Barr virus infection KEGG Pathway -3.79267986 10 More
hsa05170 Human immunodeficiency virus 1 infection KEGG Pathway -2.98955463 9 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
view
Related drugs: 19 records
Drug name Interaction type Source PMID View
ammonium trichlorotellurate NCI 9759874 view
aspirin NCI 15200494 view
asunercept TTD view
atorvastatin NCI 16796407 view
bcg vaccine NCI 11359651 view
cholecalciferol NCI 9811059 view
cisplatin NCI 9935158 view
cyclophosphamide NCI 11437491 view
daunorubicin NCI 10216102 view
edelfosine NCI 16540473 view
floxuridine NCI 11115403 view
fluorouracil NCI 12845662 view
lithium NCI 15475000 view
ofranergene obadenovec TTD view
progesterone NCI 14659903 view
teniposide NCI 9543255 view
testosterone NCI 10809356 view
thrombin NCI 16271051 view
vesnarinone NCI 9226479 view
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
NM_000043.6:c.-670G>A genomics acute myocardial infarction[diagnosis] acute myocardial infarction Hanasaki H et al. Hypertens Res. 2009
tumor necrosis factor receptor superfamily member 6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Ohtsuka T et al. Coron Artery Dis. 1999
tumor necrosis factor receptor superfamily member 6 proteomics old myocardial infarction[diagnosis] old myocardial infarction Ohtsuka T et al. Coron Artery Dis. 1999
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